Diagnosis and surgical treatment of tumor-induced osteomalacia—a literature review and a case report

Abstract Background Tumor-induced osteomalacia (TIO) is a rare condition with fewer than 500 cases reported in the literature although described. Phosphaturic mesenchymal tumor (PMT) often unrecognized cause of hypophosphatemia. This case report aims to highlight such association which warrants clinical and radiologist attention. Case A 51-year-old man had pain his feet 2 years prior most recent presentation our clinic. The patient experienced increasingly severe body aches pain, affected feet, hips, knees, ribs, waist, shoulders. MRI CT led diagnosis multiple insufficiency fractures. Laboratory tests showed that inorganic phosphate (IP) levels decreased 0.52 mmol/L(0.81–1.45 mmol/L), while alkaline phosphatase (ALP) increased 216 U/L(38.0–126.0 U/L). Positron emission tomography computed tumor-derived hypophosphate right iliac wing; surgical resection was performed. markers bone metabolism density returned normal postoperative, after 9 months follow-up. Conclusion possibility tumor-induced should be considered if unexplained joint mineral density, ALP fractures, no similar family history are found adult patients. Surgical key treatment.